特发性正常压力性脑积水患者腰腹腔分流术的

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TodiscoM,PicasciaM,PisanoP,etal.Lumboperitonealshuntinidiopathicnormalpressurehydrocephalus:aprospectivecontrolledstudy[publishedonlineaheadofprint,May5].JNeurol.;10./s---x.doi:10./s---x

特发性正常压力性脑积水患者腰腹腔分流术的前瞻性对照研究

Objective:Inthisprospective,controlled,monocentricstudy,wedescribedtheclinicalandneuroimaging12-monthfollow-upoftwoparallelcohortsofsubjectswithidiopathicnormalpressurehydrocephalus(iNPH),whodidordidnotundergolumboperitonealshunt(LPS).

目的：在这项前瞻性对照单中心研究中，我们对两组平行队列的特发性正常压力性脑积水（iNPH）患者进行了为期12个月的临床和神经影像学随访，这些患者接受或不接受腰腹腔分流术（LPS）。

Methods:Werecruited78iNPHpatients.Atbaseline,subjectsunderwentclinicalandneuropsychologicalassessments,3Tmagneticresonanceimaging(MRI),andtaptest.Afterbaseline,44patients(LPSgroup)optedforLPSimplantation,whereas34subjects(controlgroup)declinedsurgery.Bothcohortswerethenfollowedupfor12monthsthroughscheduledclinicalandneuropsychologicalevaluationsevery6months.3TMRIwasrepeatedat12-monthfollow-up.

方法：收集78名iNPH患者。在基线时对患者进行临床和神经心理学评估，3T磁共振成像（MRI）和tap试验。基线后有44名患者（LPS组）选择了LPS手术，而34名患者（对照组）拒绝手术。通过每6个月进行一次临床和神经心理学评估，我们对这些患者进行了为期12个月的随访并复查3tMRI。

Results:Gait,balance,andurinarycontinenceimprovedintheLPSgroup,withoutsignificantinfluenceoncognitivefunctions.Conversely,gaitandurinarycontinenceworsenedinthecontrolgroup.NopreoperativeMRIparameterwassignificantout

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